5-Amino-1MQ

5-Amino-1MQ helps boost metabolism and energy levels by preserving NAD+, a key molecule in the body's energy production. It works by reducing fat storage, promoting weight loss, and supporting healthier blood sugar levels, while also activating genes linked to longevity and overall health. 5-Amino-1MQ is a small molecule inhibitor that targets the enzyme nicotinamide N-methyltransferase (NNMT), a key regulator of metabolism and energy balance, primarily active in fat tissue. By inhibiting NNMT, 5-Amino-1MQ elevates nicotinamide adenine dinucleotide (NAD+), a critical cofactor in cellular metabolism, leading to enhanced metabolic rates and activation of the sirtuin-1 (SIRT1) gene, often referred to as the "longevity gene." This dual action has generated significant interest in its potential for weight management, metabolic health, and anti-aging applications.

- Support weight loss by boosting metabolism and reducing fat storage, especially with a slower metabolic rate

- Increase energy levels and regulate blood sugar for overall metabolic health

How this peptide works in the body

Inhibition of NNMT and Methylation Sink Reversal

• 5-Amino-1MQ binds competitively to NNMT, blocking its conversion of nicotinamide to 1-methylnicotinamide (1-MNA). This preserves intracellular nicotinamide levels for NAD+ biosynthesis via the salvage pathway. It also limits methyl donor depletion by sparing SAM, restoring cellular methylation potential crucial for DNA, histone, and metabolic enzyme regulation.

Elevation of NAD+ and Sirtuin Activation

• By preventing nicotinamide catabolism, 5-Amino-1MQ increases NAD+ levels, fueling sirtuins (especially SIRT1 and SIRT3). These deacetylases enhance mitochondrial biogenesis, oxidative phosphorylation, and stress resistance via activation of PGC-1α, FOXO3, and AMPK. This creates a cellular environment favoring fat oxidation and longevity signaling.

Stimulation of Lipolysis and Adipocyte Remodeling

• The compound reduces the expression of adipogenic transcription factors such as PPARγ and C/EBPα while enhancing lipolytic enzymes like HSL and ATGL. It causes a phenotypic shift from white to beige adipocytes by upregulating UCP1 and PRDM16, increasing thermogenesis and basal energy expenditure.

Improvement of Glucose Homeostasis and Insulin Sensitivity

• 5-Amino-1MQ enhances glucose uptake in skeletal muscle via increased GLUT4 expression, mediated through AMPK activation. It also decreases hepatic gluconeogenesis and reduces systemic inflammation by inhibiting NF-κB signaling. These changes improve insulin signaling and reduce circulating glucose levels in insulin-resistant models.

Protection Against Age-Related Epigenetic Drift

• By increasing SAM availability and reducing aberrant methylation of histones and DNA, 5-Amino-1MQ supports epigenetic maintenance in aging cells. It stabilizes transcriptional programs involved in mitochondrial homeostasis, metabolic regulation, and autophagy, contributing to cellular rejuvenation.