Adamax is a highly potent synthetic derivative of Semax, designed to optimize brain performance and neuroprotection. It supports long-term cognitive resilience, emotional regulation, and mental clarity. Adamax is a chemically engineered nootropic peptide that combines the core neuroactive structure of Semax with two key modifications: an acetyl group that enhances stability and enables better blood-brain barrier penetration, and an adamantyl group that increases lipid solubility and protects against enzymatic degradation. These changes allow Adamax to exert stronger and more sustained cognitive effects than its predecessors, including elevated levels of Brain-Derived Neurotrophic Factor (BDNF), improved TrkB receptor sensitivity, and support for neurogenesis. Users report increased cognitive energy, reduced apathy, enhanced mood, and significant improvements in attention and memory consolidation.
Adamax
Overview
Benefits
- Rapid and sustained improvement in mental clarity and productivity
- Boosts memory consolidation and recall
- Enhances motivation and reduces apathy
- Protects against cognitive decline and neuroinflammation
- Stimulates neurogenesis and brain resilience
- Improves mood and emotional regulation
Consider This Peptide If You Want To
- Enhance focus, memory, and overall cognitive performance
- Seek neuroprotection and support for neurogenesis
- Desire long-lasting nootropic benefits with minimal stimulant-like side effects
Dosage & Administration
Dosage Guidelines
Recommended Dosage
• Amount: 100 mcg
• Frequency: daily
• Duration: 4 weeks
• Rest Period:
• Time of Day: morning
• Ingestion: intranasal
Start with the lowest effective dose and use earlier in the day to avoid sleep disruption. Can be administered as 1-3 nasal sprays depending on concentration.
Administration Routes:
- Intranasal Administration
Research Findings on Dosage:
Intranasal Administration:
- Commonly Reported Dosage: 100-300 mcg daily (1–3 sprays depending on bottle concentration).
- Duration: (5 days on / 2 days off) for 4-8 weeks.
Important Notes:
- Start with the lowest effective dose (e.g., 100 mcg/day) and gradually increase as tolerated.
- Higher doses (300 mcg+) may interfere with sleep and should be used earlier in the day.
- Can potentiate caffeine; users report reduced anxiety when combined.
Mechanism of Action
How this peptide works in the body
BDNF Upregulation:
• Adamax significantly elevates levels of brain-derived neurotrophic factor (BDNF), a protein critical for synaptic plasticity, memory, and learning. The acetylated Semax backbone promotes gene expression of BDNF in the hippocampus, enhancing long-term potentiation (LTP).
TrkB Receptor Sensitization:
• BDNF binds to TrkB (tropomyosin receptor kinase B), activating the PI3K-Akt, PLCγ1, and MAPK/ERK signaling cascades. These pathways support neuronal survival, dendritic growth, and synaptic strength. Adamax enhances TrkB sensitivity, maximizing BDNF's effects on neuroplasticity.
Neurogenesis Promotion:
• Through BDNF-TrkB axis activation, Adamax indirectly stimulates neurogenesis in the dentate gyrus of the hippocampus. This effect may be mediated by the Wnt/β-catenin pathway and CREB (cAMP response element-binding protein) activation.
Enzymatic Protection & Blood-Brain Barrier Penetration:
• The adamantyl group protects the peptide from metabolic degradation by peptidases, prolonging its half-life and enabling consistent cognitive effects. Its lipophilicity enhances permeability through the blood-brain barrier.
Stabilized Intermediate Formation:
• The N-acetyl modification leads to the formation of a stable
Consider Stacking With
- Semax (phased potentiation or transition)
- Selank (reduce anxiety while enhancing cognition)
- Lion’s Mane mushroom (additional BDNF support)
- Caffeine, low dose (potentiate focus)
Side Effects & Cautions
Common Side Effects
- Sleep disruption (high doses or late-day use)
- Overstimulation (jitteriness or restlessness)
Rare Side Effects
- Mild headache or transient nasal irritation from intranasal use
Research & References
Research Highlights
• User Reports: Long-lasting mental energy (8–10 hours) and a strong focus with fluid, creative thought.
• Cognitive Euphoria: Enhanced sensory awareness, improved emotional stability, and accelerated task execution.
• Biohacker Forums: Reported accumulation of positive cognitive benefits over weeks of use with no noted tachyphylaxis.
References
• Campbell, J. Adamax & P21: Two New Nootropic Peptides to Watch Closely. 2020.
• Reddit Nootropics Forum Archive. Anecdotal user reports on Adamax.
• Ceretropic Research Archive (Archived site materials pre-2018).
• Zhang, L. et al. Lipophilic Drug Delivery Enhancements via Adamantyl Modification. Molecules, 2018.