AOD-9604

AOD-9604 is a fragment of human growth hormone designed to promote fat loss without the side effects of hGH. It helps break down fat, reduces fat storage, and supports bone and cartilage health, making it potentially beneficial for weight management and joint repair. AOD-9604 is a modified fragment (176–191) of human growth hormone (hGH), engineered to harness the fat-burning capabilities of hGH without its adverse effects. It acts as a dual-action peptide, stimulating lipolysis (fat breakdown) and inhibiting lipogenesis (fat accumulation). In some clinical studies, AOD has displayed superior inhibition of fat production and promotion of fat breakdown than growth hormone. Frag 176-191 is a derivative of AOD, but lacks the disulfide bond, making it less stable and effective.

- Promote fat loss by stimulating fat breakdown and reducing fat storage without the side effects of full hGH

- Support joint and cartilage health for recovery or improved mobility

How this peptide works in the body

Fat Metabolism Activation:

• AOD-9604 stimulates hormone-sensitive lipase (HSL), an enzyme responsible for lipolysis (fat breakdown), by mimicking the fat-reducing actions of human growth hormone (hGH). This activation increases free fatty acid release from adipose tissue, allowing stored fat to be used for energy.

Inhibition of Fat Storage:

• By suppressing lipoprotein lipase (LPL) activity, AOD-9604 prevents the uptake and storage of triglycerides in adipose tissue. This inhibition reduces lipogenesis (fat accumulation), helping maintain a negative fat balance, particularly in visceral and subcutaneous fat deposits.

β-Adrenergic Receptor Efficiency:

• AOD-9604 enhances β-adrenergic receptor activation, improving catecholamine sensitivity in adipocytes, which boosts thermogenesis and metabolic rate. This effect increases energy expenditure, further supporting fat loss without altering growth hormone levels.

Bone Strengthening:

• AOD-9604 stimulates mesenchymal stem cells (MSCs) to undergo osteogenic differentiation, increasing bone mineralization and density. This occurs through the upregulation of bone morphogenetic proteins (BMPs) and alkaline phosphatase (ALP), which are essential for bone formation.

Cartilage Repair:

• By promoting chondrocyte proliferation and extracellular matrix production, AOD-9604 enhances collagen and proteoglycan synthesis, essential for cartilage strength and flexibility. This regenerative effect may aid in osteoarthritis relief and joint repair by preserving cartilage integrity.