BPC-157

BPC-157 is a synthetic peptide that accelerates healing, reduces inflammation, and supports tissue repair across muscles, tendons, and the gut. It also promotes gut health, protects the stomach lining, and aids recovery in injuries and neurological conditions. BPC-157 is a 15-amino acid synthetic peptide derived from a protein found in the gastric juice of humans. Known for its broad-spectrum healing properties, it promotes tissue repair, modulates angiogenesis, and supports gut-brain axis health. This peptide accelerates wound healing, reduces inflammation, and fosters cellular regeneration across multiple systems, including musculoskeletal, gastrointestinal, and neurological tissues.

- Accelerate healing and tissue repair for injuries related to muscles, tendons, ligaments, or the gastrointestinal tract

- Reduce inflammation and protect against gut damage (e.g., ulcers, leaky gut, IBD)

How this peptide works in the body

Angiogenesis Modulation:

• BPC-157 upregulates vascular endothelial growth factor (VEGF) and its receptor VEGFR2, stimulating angiogenesis (new blood vessel formation) and increasing oxygen and nutrient delivery to damaged tissues. It also enhances endothelial nitric oxide synthase (eNOS) activity, boosting nitric oxide (NO) production, which improves vasodilation and microcirculation for better tissue perfusion and healing.

Inflammation Reduction:

• BPC-157 suppresses pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6, reducing inflammatory damage and oxidative stress. It also upregulates IL-10, an anti-inflammatory cytokine, while inhibiting NF-κB activation, preventing excessive inflammatory signaling and oxidative damage. Additionally, it modulates COX-1 and COX-2 activity, balancing prostaglandin production to reduce pain and inflammation while supporting gastrointestinal mucosal protection.

Tissue Regeneration:

• BPC-157 stimulates fibroblast growth factor (FGF) pathways, enhancing fibroblast migration and proliferation for faster wound healing. It also upregulates TGF-β/Smad signaling, increasing collagen type I and III synthesis, which is crucial for connective tissue repair. By modulating integrins and laminins, it strengthens extracellular matrix (ECM) stability, ensuring proper tissue remodeling. Additionally, it increases growth hormone receptor (GHR) expression, enhancing GH-mediated repair processes.

Neuroprotection:

• BPC-157 regulates serotonergic (5-HT), dopaminergic (D1/D2), and GABAergic neurotransmitter systems, stabilizing mood, cognition, and neuroplasticity. It reduces neuroinflammation by suppressing microglial activation and cytokine release, protecting against CNS degeneration. By upregulating nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), it supports neuronal survival and synaptic plasticity, aiding nerve regeneration and repair. Additionally, it enhances Schwann cell proliferation, facilitating myelination and peripheral nerve healing.

Gut-Brain Axis Regulation:

• BPC-157 strengthens intestinal barrier function by upregulating zonula occludens-1 (ZO-1) and occludin, improving tight junction integrity and reducing gut permeability ("leaky gut"). It activates epidermal growth factor (EGF) pathways, promoting epithelial regeneration and gut lining repair. By lowering lipopolysaccharide (LPS)-induced endotoxemia, it reduces systemic inflammation and neuroimmune dysfunction. Additionally, it modulates enteric neurotransmitters (serotonin, dopamine, acetylcholine), improving gut motility and reducing symptoms of gastrointestinal disorders.