Cardiogen

Cardiogen is a synthetic peptide that supports heart health by promoting cardiac tissue repair, reducing scarring, and preventing cell death. It also shows potential in cancer research for inhibiting tumor growth and in improving prostate health and age-related tissue restoration. Cardiogen is a synthetic tetrapeptide with the amino acid sequence H-Ala-Glu-Asp-Arg-OH. It is designed as a bioregulator to promote tissue repair and regeneration, specifically targeting cardiac tissue. Cardiogen demonstrates potential in stimulating cardiac progenitor cells, inhibiting fibroblast activity, and reducing apoptosis in heart tissue. It has been studied for its roles in cardiovascular health, prostate health, and cancer research.

- Support heart health and cardiovascular function by enhancing cardiac repair and reducing oxidative stress

- Improve circulation and promote tissue regeneration for recovery from cardiovascular conditions or injuries

Mechanism of Action

How this peptide works in the body

Cardiac Tissue Regeneration:

Cardiogen stimulates the proliferation of cardiac progenitor cells, enhancing the regeneration of damaged myocardium and improving heart tissue repair. It also increases the synthesis of extracellular matrix (ECM) components, such as collagen and elastin, which are essential for maintaining cardiac structure and function after injury.

Apoptosis Regulation:

By downregulating p53 expression, Cardiogen reduces apoptosis (programmed cell death) in cardiac cells, allowing for greater cell survival under oxidative stress or ischemic conditions. This protective effect prevents excessive cardiomyocyte loss, which is crucial for post-myocardial infarction recovery.

Fibroblast Modulation:

Cardiogen inhibits fibroblast proliferation, reducing excessive collagen deposition that leads to scar tissue formation and adverse cardiac remodeling. This modulation helps preserve heart elasticity and function, reducing the risk of heart failure following injury.

Tumor Cell Apoptosis:

In cancer research, Cardiogen has been shown to induce apoptosis in specific tumor cell lines, particularly sarcomas, through the activation of pro-apoptotic signaling pathways. This suggests potential oncological applications for controlling tumor progression and promoting targeted cancer cell death.