Chelohart

Chelohart is a natural peptide bioregulator derived from cardiac muscle tissue. It is designed to support and restore the function of the heart by regulating gene expression, enhancing protein synthesis, and promoting the health of myocardial cells. Chelohart supports myocardial structure and function by modulating gene expression, normalizing cardiac metabolism, and restoring protein synthesis within cardiomyocytes. It aims to address age-related and pathological deficiencies in myocardial peptide signaling and may benefit myocarditis, CAD, ischemic heart disease, hypertension, heart failure, or post-MI recovery.

- Managing CAD, hypertension, or heart failure

- Recovering from myocardial infarction or myocarditis

- Seeking cardiovascular support during aging

- Engaging in intensive physical activity requiring cardiac support

Mechanism of Action

How this peptide works in the body

DNA Binding and Epigenetic Regulation

Chelohart contains short-chain peptides capable of entering the nucleus of cardiomyocytes and binding to specific DNA sequences in promoter regions of cardiac-specific genes. This interaction facilitates the recruitment of transcriptional machinery, leading to increased expression of genes responsible for structural and functional proteins in the heart muscle. Additionally, Chelohart influences epigenetic markers by modulating histone acetylation and DNA methylation patterns, promoting a gene expression profile conducive to cardiac health.

Transcription Factor Modulation

Chelohart modulates the activity of key transcription factors involved in cardiac function, such as GATA4 and MEF2C. By enhancing the activity of these factors, Chelohart promotes the transcription of genes essential for myocardial contractility and energy metabolism. Concurrently, it downregulates stress-associated transcription factors like NF-κB, reducing the expression of pro-inflammatory genes and mitigating inflammatory responses in cardiac tissue.

Cytokine and Inflammatory Pathway Reprogramming

Chelohart exerts anti-inflammatory effects by modulating cytokine signaling pathways. It downregulates the production of pro-inflammatory cytokines such as IL-6 and TNF-α while upregulating anti-inflammatory cytokines like IL-10. This shift in cytokine balance reduces inflammation in the myocardium, protecting cardiac cells from inflammatory damage and contributing to improved cardiac function.

Extracellular Matrix and MMP Regulation

Chelohart influences the remodeling of the extracellular matrix (ECM) in cardiac tissue by regulating the activity of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs). By maintaining a balance between MMPs and TIMPs, Chelohart prevents excessive ECM degradation, preserving the structural integrity of the heart muscle and preventing pathological remodeling associated with heart disease.

Cellular Senescence and Anti-Aging Mechanisms

Chelohart reduces markers of cellular senescence in cardiomyocytes, such as p16^INK4a and p21^CIP1, while enhancing the expression of longevity-associated proteins like SIRT1. This modulation promotes cellular longevity and function, counteracting age-related decline in cardiac performance and contributing to the maintenance of a healthy heart during aging.

Mitochondrial Support and Oxidative Stress Response

Chelohart supports mitochondrial function in cardiac cells by enhancing the expression of genes involved in mitochondrial biogenesis and energy production, such as PGC-1α. It also upregulates antioxidant enzymes like superoxide dismutase (SOD) and glutathione peroxidase (GPx), reducing oxidative stress and protecting cardiomyocytes from oxidative damage, thereby sustaining energy production and cellular health in the heart.