Chitomur

Chitomur is a natural peptide bioregulator derived from urinary bladder tissue. It supports urinary tract function by regulating gene expression, restoring peptide signaling, and enhancing protein synthesis within bladder wall cells. Its actions may help normalize urination and reduce age- or condition-related bladder dysfunction. Chitomur reactivates gene expression patterns and cellular repair mechanisms downregulated in aging or degenerative bladder conditions. It targets bladder wall epithelium and detrusor muscle cells, supporting restoration of urinary control mechanisms and aiding recovery from pelvic surgeries and bladder trauma.

- Experience urinary incontinence or overactive bladder

- Have chronic cystitis or bladder inflammation

- Recovering from bladder surgery or injury

- Seek bladder health support during aging

- Desire improved bladder muscle tone and function

Mechanism of Action

How this peptide works in the body

DNA Binding and Epigenetic Regulation

Chitomur contains short-chain peptides capable of entering the nucleus of bladder epithelial and smooth muscle cells and binding to specific DNA motifs. This interaction facilitates chromatin relaxation through histone acetylation and reduced promoter methylation, enabling expression of genes involved in cytoskeletal support, cell adhesion, and membrane transport vital to bladder function.

Transcription Factor Modulation

Chitomur activates transcription factors such as PPARγ and uroplakin-associated elements, improving epithelial integrity and barrier function. It also suppresses the expression of NF-κB and other stress-related transcription factors, reducing transcription of inflammatory and pro-apoptotic genes.

Cytokine and Inflammatory Pathway Reprogramming

Chitomur inhibits overexpression of IL-6 and TNF-α while enhancing IL-10 in urothelial and immune cells, shifting the local immune response from pro-inflammatory to regulatory. This change is linked to downregulation of the TLR4--NF-κB axis, commonly activated in interstitial cystitis and overactive bladder syndromes.

Extracellular Matrix and MMP Regulation

Chitomur modulates MMP-9 and MMP-2 activity and upregulates tissue inhibitors of metalloproteinases (TIMPs), stabilizing collagen and elastin networks in the bladder wall. This reduces fibrotic remodeling and preserves bladder compliance and contractile elasticity.

Cellular Senescence and Anti-Aging Mechanisms

Chitomur suppresses markers of senescence such as p16^INK4a and p21^CIP1 and increases sirtuin family expression (SIRT1/6), enhancing chromatin stability and DNA repair pathways. These changes maintain proliferative capacity and function in aging bladder tissue.

Mitochondrial Support and Oxidative Stress Response

By activating PGC-1α and Nrf2, Chitomur enhances mitochondrial biogenesis and antioxidant defenses, including superoxide dismutase (SOD2) and catalase. This reduces ROS-induced bladder wall damage and preserves energy metabolism necessary for detrusor contractility.