Chonluten

Chonluten is a synthetic peptide bioregulator formulated to support respiratory system resilience. By restoring protein synthesis and gene expression in bronchial and alveolar cells, it contributes to lung tissue repair, inflammation reduction, and improved breathing capacity, especially in chronic respiratory stress or age-related decline. Chonluten (Glu-Asp-Gly) targets lung epithelium and bronchial mucosa, restoring impaired gene expression and protein synthesis relevant for asthma, COPD, post-infectious damage, or environmental exposure. It stabilizes the bronchial lining, improves mucosal barrier integrity, promotes regeneration of alveolar structures, normalizes cytokine signaling, and protects lung parenchyma from oxidative stress.

- Managing asthma, COPD, or bronchitis

- Enhance lung tissue repair and regeneration

- Reduce respiratory tract inflammation

- Support respiratory health during aging

- Recover from respiratory infections or environmental lung damage

Mechanism of Action

How this peptide works in the body

DNA Binding and Epigenetic Regulation

Chonluten enters lung epithelial nuclei and binds to promoter regions of genes responsible for mucin production, tight junction proteins, and cytoskeletal remodeling (e.g., MUC5AC, claudin, actin). This interaction facilitates histone acetylation (via recruitment of histone acetyltransferases) and reduces methylation of transcriptionally active regions, restoring gene expression necessary for respiratory epithelial repair.

Transcription Factor Modulation

Chonluten modulates the activity of key transcription factors such as NF-κB (inflammatory suppression), HIF-1α (hypoxia response), and Nrf2 (oxidative stress regulation). By suppressing NF-κB and AP-1, it downregulates transcription of genes encoding IL-1β, IL-6, TNF-α, and COX-2. This leads to a reduction in airway inflammation, improved mucociliary clearance, and epithelial homeostasis.

Cytokine and Inflammatory Pathway Reprogramming

Chonluten downregulates pro-inflammatory cytokines (e.g., IL-6, IL-8, TNF-α) and promotes regulatory cytokines such as IL-10 through modulation of the JAK/STAT and TLR4 pathways. This reduces recruitment of neutrophils and macrophages to lung tissue, limiting mucus hypersecretion and alveolar damage in inflammatory airway diseases.

Extracellular Matrix and MMP Regulation

Chonluten helps preserve alveolar integrity by regulating the balance between MMP-9 and TIMP-1, which govern extracellular matrix remodeling. By preventing collagen breakdown and fibrotic scarring, it helps maintain pulmonary compliance and prevents excessive airway remodeling.

Cellular Senescence and Anti-Aging Mechanisms

Chonluten reduces markers of cell cycle arrest in aging pulmonary cells, including p16^INK4a and p21^CIP1, while upregulating sirtuin family proteins (SIRT1 and SIRT6). These proteins support genomic stability, DNA repair, and mitochondrial efficiency, reducing senescence-associated secretory phenotypes (SASP) in bronchial epithelium.

Mitochondrial Function and Oxidative Stress Response

Chonluten enhances mitochondrial biogenesis by activating PGC-1α and downstream transcriptional coactivators (NRF1/2). It boosts antioxidant defenses by activating the Nrf2 pathway, leading to increased expression of heme oxygenase-1 (HO-1), superoxide dismutase (SOD), and glutathione peroxidase (GPx). These effects protect respiratory cells from ROS-induced apoptosis and support energy metabolism required for regeneration.