CJC-1295 is a synthetic peptide that boosts growth hormone (GH) and IGF-1 levels, promoting muscle growth, fat loss, improved sleep, and anti-aging effects. It is often combined with Ipamorelin for enhanced results in recovery, performance, and metabolism. CJC-1295 is a synthetic analogue of growth hormone-releasing hormone (GHRH) designed to increase growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels in the body. This peptide mimics the action of natural GHRH but has been modified for increased stability and resistance to enzymatic degradation. CJC-1295 is available in two forms: with DAC (Drug Affinity Complex) for extended action and without DAC for a more pulsatile release of GH. When combined with Ipamorelin, a growth hormone-releasing peptide (GHRP), the synergistic effects amplify GH release, improving muscle mass, fat loss, recovery, sleep quality, and overall performance. This combination is often used in anti-aging, performance enhancement, and therapeutic protocols.
CJC-1295
Also known as: Modified GRF (1-29); CJC-1295 DAC
Overview
Benefits
- Muscle growth and recovery
- Fat loss
- Improved sleep quality
- Anti-aging effects
- Enhanced performance
- Better bone health
- Neuroprotection
Consider This Peptide If You Want To
- Enhance growth hormone production to support muscle growth, fat loss, and overall recovery
- Improve sleep quality, cellular repair, and anti-aging benefits for long-term health and performance
Dosage & Administration
Dosage Guidelines
Recommended Dosage
• Amount:100 mcg
• Frequency:twice weekly
• Duration:8 weeks
• Rest Period:8 weeks
• Time of Day:morning
• Ingestion:subcutaneous
Administration Routes:Subcutaneous
Research Findings on Dosage:
• CJC-1295 With DAC :
◦ Commonly Reported Dosage: subcutaneous injection - 100 mcg twice per week (more is not better)
◦ Duration: 6-8 week cycles, 4-8 week rest
▪ Note: Recommended to take on an empty stomach 30 minutes before or 2 hours after eating
• CJC-1295 Without DAC (Mod GRF 1-29):
◦ Commonly Reported Dosage: subcutaneous injection - 100 mcg, 5 days on, 2 days off
◦ Duration: 10-12 week cycles, 4-8 weeks off
▪ Note: Recommended to take on an empty stomach 30 minutes before or 2 hours after eating. Multiple injections can be given per day to increase GH secretion
▪ Best practice: Recommended to test IGF-1 levels before administration of any GHRP, GHRH
• CJC-1295 + Ipamorelin Combination:
◦ Commonly Reported Dosage: 200--400 mcg daily, 5 days on, 2 days off
◦ Duration: 90 days
▪ Note: Recommended to take on an empty stomach
▪ Best practice is to titrate to avoid a histamine response
Mechanism of Action
Mechanism of Action
How this peptide works in the body
CJC-1295 binds to growth hormone-releasing hormone (GHRH) receptors in the anterior pituitary, triggering the cyclic AMP (cAMP)-dependent activation of protein kinase A (PKA). This leads to growth hormone (GH) secretion, which stimulates anabolic processes such as protein synthesis, muscle growth, and tissue repair while also enhancing lipolysis (fat breakdown).
IGF-1 Stimulation:
By increasing GH release, CJC-1295 elevates insulin-like growth factor-1 (IGF-1) levels, which is primarily produced in the liver via JAK2/STAT5 signaling. IGF-1 promotes cellular growth, enhances metabolism, and supports musculoskeletal and neurological regeneration, making it key for anti-aging, athletic recovery, and fat loss.
Pulsatile vs. Sustained Release:
Without DAC (Mod GRF 1-29): Mimics natural GH pulsatility, producing short bursts of GH that align with the body's circadian rhythm, optimizing muscle growth and recovery.
With DAC: Binds to albumin, extending its half-life to up to 8 days, leading to a more prolonged elevation of GH and IGF-1 levels, beneficial for long-term metabolic enhancement and anti-aging applications.
With DAC: Binds to albumin, extending its half-life to up to 8 days, leading to a more prolonged elevation of GH and IGF-1 levels, beneficial for long-term metabolic enhancement and anti-aging applications.
Consider Stacking With
- Any GHRP (Ipamorelin, Hexarelin)
- BPC-157
- AOD-9604
- Semaglutide/Tirzepatide
- PEG-MGF
- Kisspeptin-10
- 5-Amino-1MQ
Side Effects & Cautions
Common Side Effects
- Flushing
- Injection site irritation
- Fatigue
- Joint pain
- Mild swelling (edema)
Cautions
- Cell proliferation: use cautiously in cancer-prone individuals due to GH’s potential mitogenic effects
- Thyroid suppression: monitor thyroid levels, as GH can suppress TSH
- WADA restrictions: banned for competitive athletes
- Potential for histamine response
Research & References
Research Highlights
Extended GH and IGF-1 Release: Studies show CJC-1295 can sustain elevated GH levels for up to 6 days and IGF-1 levels for 9--11 days with a single dose.
Fat Loss and Body Composition: Clinical trials indicate reduced visceral fat and improved metabolic profiles in treated subjects.
Teichman SL, et al. "Prolonged stimulation of GH and IGF-1 by CJC-1295." J Clin Endocrinol Metab. 2006
ConjuChem Technologies. "Development and pharmacokinetics of CJC-1295 DAC." 2021
Perras B, et al. "Regulation of sleep and endocrine function by GHRH." Endocrinol Metab. 2021
Fehm HL, et al. "GHRH effects on sleep quality." Psychoneuroendocrinology. 1999
ConjuChem Technologies. "Development and pharmacokinetics of CJC-1295 DAC." 2021
Perras B, et al. "Regulation of sleep and endocrine function by GHRH." Endocrinol Metab. 2021