Cortexin

Cortexin is a neuroprotective peptide that enhances brain metabolism, reduces oxidative stress, and supports cognitive functions like memory and learning. It is used for stroke recovery, neurodevelopmental disorders, and neurodegenerative conditions, offering protection and repair for neurons. Cortexin is a neurotrophic peptide extracted from animal cerebral cortex tissue, composed of low molecular weight polypeptides, amino acids, vitamins, and trace elements. It acts as a nootropic, neuroprotective, antioxidant, and tissue-specific agent. Cortexin is used to treat various neurological disorders, improve cognitive functions, and enhance the brain's resilience to stress. Its mechanisms promote neuroprotection, improve learning and memory, and support brain metabolism.

- Enhance cognitive function, memory, and mental clarity for neuroprotection and brain optimization

- Support recovery from stroke, TBI, or neurodegenerative disease

Mechanism of Action

How this peptide works in the body

Neuroprotection:

Cortexin reduces oxidative stress by inhibiting lipid peroxidation and neutralizing free radicals, preventing damage to neuronal membranes. It also modulates glutamatergic signaling, reducing excitotoxicity caused by excessive NMDA receptor activation, which can lead to neuronal apoptosis and neurodegeneration.

Cognitive Enhancement:

By optimizing the balance of excitatory and inhibitory neurotransmitters, including dopamine, serotonin, and GABA, Cortexin enhances synaptic plasticity and cognitive functions. This supports memory consolidation, attention regulation, and learning capacity, making it beneficial for neurodevelopmental and neurodegenerative conditions.

Antioxidant Activity:

Cortexin enhances cellular antioxidant defenses, improving neuronal survival under oxidative stress and hypoxic conditions. It increases superoxide dismutase (SOD) and glutathione (GSH) levels, which reduce reactive oxygen species (ROS)-induced damage in brain tissue.

Tissue-Specific Effects:

Cortexin stimulates neurotrophic factor signaling, promoting neuronal growth and repair in the central and peripheral nervous systems. It accelerates axonal regeneration and synapse formation, enhancing neural network stability and recovery after injury.

Mitochondrial Function:

Cortexin restores ATP synthesis in neurons by improving mitochondrial respiration and oxidative phosphorylation efficiency, ensuring adequate cellular energy production. This is critical for neuronal survival during ischemia, injury, or degenerative processes.