Dihexa

Dihexa is a neuroprotective peptide that enhances memory, learning, and neural repair by activating growth factors like HGF. It supports synaptic growth, protects against neurodegenerative diseases, and promotes recovery from cognitive decline and motor impairments. Dihexa is a synthetic oligopeptide derivative of angiotensin IV. It is highly BBB-permeable and binds with high affinity to HGF, amplifying neurotrophic and regenerative effects. It improves cognitive function, facilitates synaptogenesis, and promotes neural repair, especially in neurodegenerative disease models.

- Enhance cognitive function, memory, and learning (neurodegeneration or cognitive decline)

- Support neural regeneration and synaptic growth for long-term neurological health

Mechanism of Action

How this peptide works in the body

Angiogenesis Modulation:

Dihexa binds with high affinity to hepatocyte growth factor (HGF) and its receptor c-Met, activating the HGF/c-Met signaling pathway, which promotes neuronal growth, survival, and synaptic repair. This pathway also enhances angiogenesis, increasing blood flow and nutrient delivery to the brain, which supports cognitive function and neuroregeneration.

Inflammation Reduction:

By modulating HGF-related pathways, Dihexa reduces neuroinflammation by suppressing pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) and inhibiting microglial overactivation. This leads to reduced oxidative stress and neurotoxic damage, protecting dopaminergic and cholinergic neurons from degeneration.

Tissue Regeneration:

Dihexa stimulates synaptogenesis and dendritic arborization by increasing neuronal connectivity and plasticity through c-Met/PI3K/Akt and MAPK/ERK signaling cascades. This enhances axon outgrowth and synaptic remodeling, facilitating neural repair in conditions like stroke, Alzheimer's, and Parkinson's disease.

Neuroprotection:

Dihexa shields neurons from excitotoxicity and oxidative stress by modulating glutamatergic signaling, preventing excess NMDA receptor activation that leads to calcium overload and neuronal apoptosis. Additionally, it enhances mitochondrial function and ATP production, improving neuronal energy efficiency and survival under stress conditions.

Gut-Brain Axis Regulation:

Through its effects on synaptic connectivity and neurotrophic signaling, Dihexa stabilizes neural networks involved in mood regulation. This indirect neuromodulation of the gut-brain axis may help reduce anxiety, nervousness, and cognitive fluctuations by optimizing neural communication between the central and enteric nervous systems.