FGL(L)

Also known as: Fibroblast Growth Loop Peptide; FGFR Agonist

Overview

FGL(L) enhances memory, learning, and neuroprotection by activating fibroblast growth factor receptors (FGFR) to support neuronal growth and synaptic plasticity. It reduces oxidative stress, promotes brain repair, and strengthens synaptic connections. FGL(L) is a synthetic peptide that mimics NCAM by acting as an agonist for FGFR1. It promotes neuronal growth, survival, and synaptic plasticity via FGFR-mediated pathways. FGL increases AMPA receptor availability and activates PKC signaling, supporting neurogenesis, memory formation, and neuroprotection.

Benefits

- Enhanced memory and learning

- Neuroprotection

- Improved synaptic strength

- Better neuronal growth

Consider This Peptide If You Want To

- Enhance cognitive function, memory, and neural plasticity

- Support nerve regeneration and synaptic repair for long-term neurological health

Dosage & Administration

Dosage Guidelines

Recommended Dosage

• Amount:1 mg

• Frequency:weekdays

• Duration:6 weeks

• Rest Period:

• Time of Day:morning

• Ingestion:subcutaneous

Administration Routes:SubcutaneousIntranasal

Research Findings on Dosage:

1. Subcutaneous Injection:

◦ Commonly Reported Dosage: 1--2 mg daily (People in their 30s and younger achieve better results with 1 mg - low dose)

◦ Duration: 5 days on, 2 days off, 6 week cycle

i. Note: FGL can also be administered via intranasal spray.

Mechanism of Action

How this peptide works in the body

Neuron Growth and Survival:

FGL(L) binds to fibroblast growth factor receptors (FGFRs), particularly FGFR1, mimicking the activity of neural cell adhesion molecules (NCAMs) and activating mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) pathways. These signaling cascades promote neuronal survival, differentiation, and axonal outgrowth, supporting brain plasticity and repair.

Synaptic Plasticity and Transmission:

FGL(L) modulates synaptic activity by enhancing AMPA receptor availability and activating the protein kinase C (PKC) pathway, which regulates excitatory synapse strength and synaptogenesis. This effect optimizes synaptic maturation and neurotransmission, facilitating long-term potentiation (LTP), which is crucial for memory formation and cognitive function.

Oxidative Stress Reduction:

By inhibiting oxidative stress-induced neuronal apoptosis, FGL(L) reduces mitochondrial dysfunction and lipid peroxidation in brain tissue. It increases antioxidant enzyme activity (e.g., superoxide dismutase (SOD) and glutathione (GSH)), protecting neurons from reactive oxygen species (ROS)-mediated damage and slowing neurodegeneration.

Signaling Enhancement:

FGL(L) amplifies FGFR-mediated signaling, leading to increased expression of neurotrophic factors like brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). This enhancement supports neural remodeling, axon regeneration, and overall synaptic strength, aiding in cognitive resilience and neuroprotection.

Consider Stacking With

- Any GHRP (Ipamorelin, Hexarelin)

- Any GHRH (CJC-1295, MOD-GRF-129, Tesamorelin)

- Cerebrolysin

- Semax/Selank

- BPC-157

- TB-4

- Epitalon

- Dihexa

- PE-22-88

Side Effects & Cautions

Common Side Effects

- Injection site redness, itching, swelling

Rare Side Effects

- Occasional nausea at higher doses

Research & References

Research Highlights

**Memory Enhancement:

**Improved memory retention and learning capabilities in animal models treated with FGL(L).

**Synaptic Plasticity:

**Promotes synaptic maturation and activity-dependent synaptic strength through FGFR activation.

**Neurodegeneration:

**Demonstrated protective effects against oxidative stress-induced neuronal damage in preclinical studies.

**Tissue Repair:

**Supported neuronal tissue repair and reduced neurodegenerative damage in experimental models.

References

FGL Peptide Enhances Cognitive Functions via FGFR Activation: PubMed Link

Neuroprotection and Synaptic Maturation Mediated by FGL(L): PubMed Link

Role of FGFR1 in Neuronal Growth and Repair: Semantics Scholar Link