GHK-Cu

GHK-Cu is a naturally occurring copper-binding tripeptide that supports tissue repair, collagen synthesis, angiogenesis, and stem cell activity. It promotes skin regeneration, hair growth, and neuroprotection while providing antioxidant and anti-inflammatory effects.

- Promote skin rejuvenation, collagen production, and wound healing

- Support hair growth and general tissue repair

Mechanism of Action

How this peptide works in the body

Copper Ion Binding and Enzyme Activation:

GHK-Cu binds to copper ions (Cu²⁺), forming a stable complex that facilitates enzymatic reactions essential for tissue remodeling. This complex activates lysyl oxidase (LOX), an enzyme required for collagen and elastin cross-linking, which strengthens skin, connective tissues, and wound healing responses.

Gene Expression Modulation:

GHK-Cu functions as an epigenetic modulator, upregulating genes involved in tissue regeneration (e.g., COL1A1 for collagen synthesis) while downregulating pro-inflammatory cytokines (IL-6, TNF-α). This dual action enhances cellular repair and reduces inflammation, contributing to anti-aging and regenerative effects.

Metalloproteinase Regulation:

GHK-Cu inhibits matrix metalloproteinases (MMPs), enzymes responsible for collagen degradation, while activating tissue inhibitors of metalloproteinases (TIMPs). This regulation preserves extracellular matrix integrity, reducing skin aging, wrinkle formation, and tissue breakdown.

Angiogenesis Induction:

GHK-Cu stimulates vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) pathways, promoting new blood vessel formation. This increased angiogenesis enhances oxygen and nutrient delivery, accelerating wound healing, skin regeneration, and hair follicle nourishment.

Glycosaminoglycan Synthesis:

GHK-Cu promotes the production of glycosaminoglycans like hyaluronic acid, which improves skin hydration, elasticity, and barrier function. This contributes to wrinkle reduction, tissue plumpness, and overall skin rejuvenation.

Anti-Inflammatory Pathways:

By suppressing nuclear factor kappa B (NF-κB) signaling, GHK-Cu reduces chronic inflammation and oxidative stress. This protective mechanism lowers cellular aging rates, supports immune regulation, and minimizes inflammatory skin conditions.

Stem Cell Activation:

GHK-Cu recruits stem cells and stimulates fibroblast proliferation, accelerating tissue repair and regeneration. This effect is critical for wound healing, muscle recovery, and hair follicle restoration, making it beneficial for anti-aging and hair growth applications.