GHRP-6 is a ghrelin-mimetic GH secretagogue that activates GHSR in the hypothalamus and pituitary to increase GH release. It supports muscle growth, fat loss, tissue repair, appetite stimulation, recovery, and sleep quality.
GHRP-6
Also known as: Growth Hormone Releasing Peptide 6
Overview
Benefits
- Muscle growth and repair
- Enhanced fat loss
- Better body composition
- Increased appetite
- Improved wound healing
- Anti-aging support
- Better sleep
Consider This Peptide If You Want To
- Stimulate GH for muscle growth, fat loss, and recovery
- Increase appetite and metabolic drive
Dosage & Administration
Dosage Guidelines
Recommended Dosage
• Amount:100 mcg
• Frequency:weekdays
• Duration:10 weeks
• Rest Period:8 weeks
• Time of Day:morning
• Ingestion:subcutaneous
Administration Routes:Subcutaneous
Research Findings on Dosage:
• Subcutaneous Injection:
◦ Commonly Reported Dosage: 100-300 mcg 1-3 times daily, 5 days on, 2 days off
◦ Enhanced Protocol: 200-300 mcg per dose when stacked with GHRH analogs.
◦ Duration: 10-12 week cycles, followed by 4-8 week break to prevent receptor desensitization.
• Administration Notes:
◦ Administer on an empty stomach 30 minutes before eating/2 hours after eating to enhance GH release.
Mechanism of Action
Mechanism of Action
How this peptide works in the body
GHSR Activation:
GHRP-6 binds to the growth hormone secretagogue receptor (GHSR-1a) in the hypothalamus and anterior pituitary gland, mimicking ghrelin's action and stimulating growth hormone (GH) secretion. This activation triggers the cAMP and phospholipase C (PLC) pathways, leading to enhanced GH pulsatility and anabolic effects.
GH Secretion Stimulation:
GHRP-6 bypasses somatostatin-mediated GH inhibition by reducing hypothalamic somatostatin release, allowing more frequent and sustained GH pulses. This leads to higher IGF-1 production, enhancing muscle growth, fat metabolism, and tissue repair.
Appetite Regulation:
By activating ghrelin receptors, GHRP-6 stimulates hunger signals in the hypothalamus, promoting increased caloric intake and energy balance. This effect is beneficial for individuals with appetite loss, metabolic disorders, or muscle-wasting conditions.
Metabolic Support:
GHRP-6 enhances fat metabolism by increasing GH-induced lipolysis, leading to greater fat breakdown and improved body composition. This process shifts energy utilization toward fatty acid oxidation, making it beneficial for fat loss and metabolic regulation.
Muscle Growth and Recovery:
By elevating IGF-1 levels, GHRP-6 supports protein synthesis, muscle hypertrophy, and tissue regeneration. This accelerates post-injury recovery, enhances strength gains, and improves wound healing, making it valuable for performance enhancement and anti-aging applications.
Consider Stacking With
- Any GHRH (CJC-1295, MOD-GRF-1295, Tesamorelin)
- BPC-157
- TB-4
- IGF-1 LR3
- PEG-MGF
- Kisspeptin-10
- 5-Amino-1MQ
- Semaglutide/Tirzepatide
Side Effects & Cautions
Common Side Effects
- Injection site reactions (redness, itchiness, swelling)
- Water retention
Cautions
- Anxiety or depression with extended use
- Increased cortisol and prolactin
- Avoid with active cancer or uncontrolled diabetes
- Monitor glucose/insulin sensitivity during prolonged use
Research & References
Research Highlights
Growth Hormone Secretion: Studies demonstrate a significant increase in plasma GH levels following GHRP-6 administration.
Appetite Stimulation: Clinical trials confirm appetite stimulation and weight gain potential.
Muscle Recovery and Fat Loss: Research supports its use for muscle recovery and fat reduction.
References
Müller, E. E., et al. (1999). "Growth hormone-releasing peptides and their applications in endocrinology." Endocrine Reviews
Smith, R. G., et al. (1996). "Ghrelin receptor agonists: Potential roles in metabolic and growth disorders." Nature Medicine
Ghigo, E., et al. (2001). "GHRP-6: Mechanism of action and clinical applications." Journal of Endocrinology and Metabolism