Glandokort is a Cytomax-class adrenal peptide bioregulator that delivers short-chain peptides targeting adrenal cortex cells. It aims to normalize gene expression, restore steroidogenesis balance, and promote cellular repair to improve stress response, energy metabolism, and endocrine stability.
Glandokort
Also known as: Peptide Complex A-17
Overview
Benefits
- Supports adrenal function and hormone production
- Helps normalize cortisol and HPA axis regulation
- Enhances stress resilience and energy metabolism
- Promotes adrenal tissue regeneration
- Contributes to hormonal balance and vitality
- May reduce symptoms of chronic fatigue/burnout
Consider This Peptide If You Want To
- Experience stress intolerance, low energy, or dysregulated cortisol
- Seek HPA axis balance and improved resilience
Dosage & Administration
Dosage Guidelines
Recommended Dosage
• Amount:30 mg
• Frequency:daily
• Duration:4 weeks
• Rest Period:12 weeks
• Time of Day:morning
• Ingestion:oral
Best taken 15–20 minutes before meals. Consider morning dosing for cortisol rhythm support.
Administration Routes:OralSublingual
Research Findings on Dosage:
Oral Administration:
• Commonly Reported Dosage: 1-2 capsules (0.215 g each) twice daily (this equates to 20-40 mg of peptide complex A-17)
• Duration: 30 days, repeated every 3--6 months
Sublingual Administration (Glandokort Lingual):
• Commonly Reported Dosage: 5--6 drops (0.25--0.35 mL), 3--4 times daily
• Duration: 30 days, repeated every 3--6 months
Administration Notes:
• Best taken 15--20 minutes before meals
• Sublingual route may offer faster systemic absorption
Mechanism of Action
Mechanism of Action
How this peptide works in the body
DNA Binding and Transcriptional Regulation
Glandokort peptides bind to AT-rich promoter regions of genes regulating adrenal steroidogenesis. This promotes transcription of key enzymes like CYP11B1 and StAR, which are critical for cortisol and aldosterone biosynthesis. Histone acetylation via HAT recruitment facilitates chromatin decondensation, enhancing gene accessibility in adrenal cortex cells.
HPA Axis Modulation
By influencing adrenal sensitivity to ACTH (adrenocorticotropic hormone), Glandokort helps normalize the feedback loop of the hypothalamic-pituitary-adrenal axis. This ensures appropriate cortisol response to physical or emotional stress while preventing hypercortisolism or adrenal exhaustion.
Intracellular Signaling via cAMP/PKA Pathway
The peptides activate second-messenger cascades, particularly the cAMP/PKA signaling pathway within zona fasciculata cells of the adrenal cortex. This enhances synthesis of glucocorticoids, leading to improved metabolic control and stress adaptation.
Epigenetic Control of Steroidogenic Genes
Glandokort modulates chromatin structure through histone modifications, affecting long-term expression of genes like CYP17A1 and HSD3B2. These genes are essential in the conversion of cholesterol to adrenal corticosteroids, contributing to stable hormonal output.
Cellular Regeneration and Anti-Aging Effects
The peptides stimulate expression of regenerative markers such as IGF-1 and anti-apoptotic proteins, promoting tissue resilience and longevity of adrenal cells. This is especially important in aging populations where adrenal involution contributes to fatigue and endocrine dysregulation.
Consider Stacking With
- Epitalon
- Thymalin
- Ventfort
- Cerluten
- Vladonix
Side Effects & Cautions
Common Side Effects
- None commonly reported
Cautions
- Use under medical supervision with adrenal disorders or corticosteroid therapy
- Not recommended with hypersensitivity to animal-derived peptides
Research & References
Research Highlights
Glandokort peptides have been shown to enhance the activity of steroidogenic enzymes in adrenal cells, supporting physiological cortisol production
Studies in elderly patients demonstrate improved energy levels and resilience to stress after a 30-day course
Use of adrenal peptides like Glandokort may support faster recovery from stress-induced adrenal suppression
Long-term administration contributes to sustained adrenal tissue function and improved hormonal profiles in aging populations
References
Khavinson VK, Malinin VV. "Peptide Bioregulators: A New Class of Geroprotectors." Biogerontology. 2005;6(3):197-204.
Morozov VG, Khavinson VK. "Peptide regulation of age-related changes in the adrenal glands." Bulletin of Experimental Biology and Medicine. 2004;137(5):515-518.
Khavinson VK, Ryzhak GA. "Effect of peptide bioregulators on hormonal balance and stress adaptation." Neuro Endocrinol Lett. 2002;23 Suppl 3:11-144.