Glutathione

Glutathione (GSH) is a tripeptide (glycine-cysteine-glutamate) and a central intracellular antioxidant that supports detoxification, redox balance, immune function, and cellular repair. Levels decline with age, increasing oxidative stress and impairing cellular performance.

- Support detoxification and antioxidant defense to reduce oxidative stress

- Promote immune function and skin health for wellness, anti-aging, and liver support

Mechanism of Action

How this peptide works in the body

Antioxidant Defense:

Glutathione neutralizes free radicals by donating electrons, preventing oxidative damage to DNA, proteins, and lipids. It plays a crucial role in reducing hydrogen peroxide (H₂O₂) and lipid peroxides via glutathione peroxidase (GPx), protecting cells from oxidative stress-induced apoptosis.

Redox Homeostasis:

As a central regulator of the cellular redox state, glutathione maintains cysteine residues in proteins in a reduced state, preventing protein misfolding and oxidative damage. The glutathione/glutathione disulfide (GSH/GSSG) ratio is a key indicator of cellular health and metabolic stability.

Detoxification:

Glutathione binds to toxins, heavy metals, and xenobiotics, facilitating their conversion into water-soluble conjugatesvia glutathione S-transferase (GST). These modified compounds are then excreted through bile and urine, reducing toxic load and liver stress.

Immune Regulation:

Glutathione enhances T-cell proliferation, macrophage activation, and leukocyte function, ensuring efficient immune responses. It also modulates inflammatory cytokine production, preventing excessive immune activation and autoimmune dysregulation.

Protein Synthesis and Repair:

Glutathione is involved in protein folding and DNA repair by maintaining cysteine thiol groups in their active forms. It also facilitates enzymatic detoxification through glutathione peroxidase (GPx) and glutathione reductase (GR), ensuring cellular resilience against oxidative stress.