Gotratix

Gotratix is a muscle-derived peptide bioregulator targeting myocytes to normalize metabolism, enhance functional activity, and reduce fatigue. Clinical reports note increased reserve capacity of muscle tissue and decreased fatigue under intense exertion.

- Experience age-related muscle weakness or sarcopenia

- Engage in high-intensity activity and seek fatigue reduction

- Aim to support muscle recovery and endurance

Mechanism of Action

How this peptide works in the body

Modulation of Oxidative Stress and Lipid Peroxidation

Intense physical activity increases mitochondrial respiration in muscle cells, leading to elevated production of reactive oxygen species (ROS) such as superoxide anions (O₂⁻), hydrogen peroxide (H₂O₂), and hydroxyl radicals (•OH).These ROS can initiate lipid peroxidation, damaging cellular membranes and impairing muscle function.

Gotratix peptides are believed to exert antioxidant effects through several mechanisms:

Enhancement of Endogenous Antioxidant Enzymes: Gotratix may upregulate the expression and activity of key antioxidant enzymes, including superoxide dismutase (SOD), which catalyzes the dismutation of superoxide anions into H₂O₂; catalase, which converts H₂O₂ into water and oxygen; and glutathione peroxidase (GPx), which reduces lipid hydroperoxides to their corresponding alcohols and free hydrogen peroxide to water.

Inhibition of Lipid Peroxidation: By enhancing antioxidant defenses, Gotratix may reduce the formation of lipid hydroperoxides (LOOH), thereby protecting muscle cell membranes from oxidative damage.

Regulation of Redox-Sensitive Signaling Pathways: Gotratix may influence redox-sensitive transcription factors such as nuclear factor erythroid 2--related factor 2 (Nrf2), which binds to antioxidant response elements (ARE) in the DNA, promoting the expression of various cytoprotective genes involved in antioxidant defense.

Promotion of Muscle Protein Synthesis and Regeneration

Gotratix peptides may support muscle regeneration and hypertrophy through the following pathways:

Activation of the PI3K/Akt/mTOR Pathway: This signaling cascade is crucial for muscle protein synthesis. Gotratix may activate phosphoinositide 3-kinase (PI3K), leading to the phosphorylation and activation of Akt (protein kinase B), which in turn activates the mammalian target of rapamycin (mTOR). Activated mTOR stimulates protein synthesis by phosphorylating downstream targets such as p70S6 kinase and 4E-BP1.

Upregulation of Myogenic Regulatory Factors: Gotratix may enhance the expression of myogenic regulatory factors (MRFs) like MyoD and myogenin, which are essential for the differentiation and maturation of muscle cells.

Enhancement of Mitochondrial Function and Energy Metabolism

By mitigating oxidative stress and supporting mitochondrial integrity, Gotratix may improve ATP production efficiency in muscle cells. This enhancement in energy metabolism can lead to increased endurance and reduced fatigue during physical activity.