Hexarelin

Hexarelin is a synthetic hexapeptide GHRP that potently stimulates growth hormone release via GHS-R1a. It produces one of the strongest GH pulses in its class and also exhibits cardioprotective effects, including reduced oxidative stress and improved lipid profiles. Long-term use may induce desensitization and elevate cortisol and prolactin. Hexarelin is the strongest GHRP.

- Stimulate GH for muscle growth, fat loss, and recovery

- Improve cardiovascular health and protect against oxidative stress

Mechanism of Action

How this peptide works in the body

GH Pathway Activation:

Hexarelin binds to growth hormone secretagogue receptor 1a (GHS-R1a) in the anterior pituitary and hypothalamus, stimulating the release of growth hormone (GH). This activation triggers the cyclic AMP (cAMP) and phospholipase C (PLC) pathways, leading to the release of GH from somatotroph cells. As a result, insulin-like growth factor-1 (IGF-1) production in the liver increases, promoting muscle growth, fat metabolism, and cellular regeneration.

Cardioprotective Action:

Hexarelin reduces oxidative stress by enhancing mitochondrial superoxide dismutase (SOD) activity, which neutralizes free radicals and prevents cardiomyocyte damage. Additionally, it activates the Akt/PI3K signaling pathway, preventing cardiomyocyte apoptosis and preserving heart function. By enhancing nitric oxide (NO) production, Hexarelin improves endothelial function, vasodilation, and overall cardiac output.

Cholesterol and Lipid Regulation:

Hexarelin modulates liver enzyme activity involved in lipid metabolism, reducing triglyceride accumulation and improving cholesterol balance. By activating peroxisome proliferator-activated receptor alpha (PPAR-α), it enhances lipid oxidation and fat metabolism, supporting cardiovascular health and reducing atherosclerosis risk.

Muscle Preservation:

Hexarelin stimulates myogenesis by activating the mechanistic target of rapamycin (mTOR) pathway, promoting muscle protein synthesis and hypertrophy. It also inhibits myostatin, a negative regulator of muscle growth, allowing for greater skeletal muscle repair and regeneration.