Ipamorelin

Ipamorelin is a selective GH secretagogue and ghrelin receptor agonist that stimulates GH release while inhibiting somatostatin. It supports muscle growth, fat metabolism, bone health, and tissue repair without activating stress responses.

- Naturally boost GH for muscle, fat loss, and recovery

- Improve sleep quality and overall well-being

Mechanism of Action

How this peptide works in the body

GH Pathway Activation:

Ipamorelin binds selectively to the growth hormone secretagogue receptor (GHS-R1a) on cells in the anterior pituitary, mimicking ghrelin's GH-stimulating effects. This activation induces GH secretion via adenylate cyclase stimulation, leading to increased cyclic AMP (cAMP) production, which amplifies GH release. Additionally, elevated GH levels stimulate hepatic IGF-1 synthesis, promoting muscle growth, tissue repair, and metabolic balance.

Muscle and Bone Support:

Ipamorelin activates the mTOR signaling pathway, enhancing protein synthesis and muscle hypertrophy while preventing muscle catabolism. It also increases osteoblast activity, driving bone mineralization through GH- and IGF-1-mediated pathways, making it beneficial for bone density preservation and fracture recovery.

Metabolic Regulation:

By activating hormone-sensitive lipase (HSL), Ipamorelin enhances lipolysis and fat oxidation, supporting fat loss and improved body composition. It also optimizes glucose homeostasis by improving insulin sensitivity, reducing excess blood sugar accumulation, and enhancing metabolic efficiency.

Collagen Synthesis:

Ipamorelin upregulates collagen gene expression via the JAK/STAT pathway, stimulating fibroblast activity and extracellular matrix remodeling. This promotes skin elasticity, joint lubrication, and cartilage repair, reducing degenerative tissue breakdown and enhancing wound healing.

Digestive Support:

By activating ghrelin receptors in the enteric nervous system, Ipamorelin modulates gastrointestinal motility, improving smooth muscle contractions in the digestive tract. This effect enhances digestion, gut health, and nutrient absorption, making it beneficial for individuals with gastric motility disorders.