Libidon

Libidon is a prostate-derived peptide bioregulator that restores tissue-specific gene expression and metabolic function in the prostate, supporting hormone balance, inflammation control, and male reproductive health.

- Manage BPH, prostatitis, or reduced libido

- Support prostate and male reproductive function during aging

- Balance androgen levels

Mechanism of Action

How this peptide works in the body

Epigenetic Regulation of Prostate-Specific Genes

Libidon-derived peptides translocate to the nucleus of prostate epithelial cells and bind selectively to AT-rich sequences within regulatory regions of genes such as KLK3 (PSA), NKX3.1, and TMPRSS2. These interactions promote the recruitment of histone acetyltransferases (e.g., p300/CBP), which acetylate lysine residues on histone H3 and H4 tails, opening chromatin structure. This facilitates RNA polymerase II binding and initiation of transcription, leading to increased production of proteins that maintain epithelial differentiation, secretory function, and androgen responsiveness.

Stimulation of Protein Biosynthesis Pathways via mTOR Activation

Peptide-induced transcriptional changes lead to upregulation of ribosomal protein genes and eukaryotic initiation factors (eIF4E, eIF2B). Libidon also indirectly activates mTORC1 via amino acid-sensing mechanisms in prostate cells, likely through increased leucine and glutamine flux. This promotes phosphorylation of p70S6K and 4E-BP1, enhancing translation initiation, elongation, and ribosome biogenesis. The result is increased synthesis of cytoskeletal proteins, secretory enzymes, and tight junction components, which collectively support tissue regeneration.

Endocrine Axis Regulation via Hypothalamic Feedback Loops

Libidon modulates GnRH pulse amplitude in the hypothalamus through retrograde signaling involving GABAergic interneurons and kisspeptinergic neurons. This alters the pulsatile release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary. These gonadotropins stimulate Leydig and Sertoli cells in the testes to optimize testosterone synthesis and spermatogenesis, indirectly enhancing androgenic feedback that maintains prostate trophism and male reproductive capacity.

Antioxidant Defense Activation via Nrf2-ARE Signaling

Libidon activates the Nrf2 (nuclear factor erythroid 2-related factor 2) pathway by promoting dissociation of Nrf2 from its cytoplasmic inhibitor Keap1. Once translocated into the nucleus, Nrf2 binds to antioxidant response elements (AREs) in the promoters of genes such as SOD1, GPx1, and HO-1. This upregulation increases cellular capacity to neutralize ROS and peroxides, preventing DNA damage, lipid peroxidation, and mitochondrial dysfunction in prostate cells exposed to inflammatory or oxidative stress.

Immunomodulation via NF-κB Inhibition and Cytokine Rebalancing

Libidon peptides interfere with the classical NF-κB activation cascade by stabilizing IκBα and inhibiting IKKβ phosphorylation. This prevents nuclear translocation of the p65/p50 dimer, thereby reducing transcription of pro-inflammatory cytokines (e.g., TNF-α, IL-6, IL-1β) and adhesion molecules (e.g., ICAM-1). Additionally, Libidon promotes a macrophage phenotype shift from M1 (pro-inflammatory) to M2 (anti-inflammatory) through enhanced IL-10 and TGF-β1 expression. This creates a tissue environment conducive to immune tolerance and epithelial healing.