Mechano Growth Factor (MGF)

MGF is an IGF-1 splice variant induced by mechanical stress that activates satellite cells and increases protein synthesis to aid muscle repair, growth, and tissue regeneration. It may also support neuroprotection and reduce inflammation.

- Enhance muscle growth and recovery

- Support tissue healing and reduce muscle loss

Mechanism of Action

How this peptide works in the body

Muscle Growth and Repair:

Mechano Growth Factor (MGF) binds to insulin-like growth factor-1 receptors (IGF-1R) on muscle cells, activating the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway. This cascade enhances mammalian target of rapamycin (mTOR) activation, which drives protein synthesis and muscle hypertrophy. Additionally, MGF stimulates the proliferation and differentiation of satellite cells, the muscle stem cells responsible for tissue repair and growth following mechanical stress or injury.

Tissue Regeneration:

MGF upregulates the expression of myogenic regulatory factors (MRFs), including MyoD and Myf5, which are essential for muscle regeneration and differentiation. This facilitates the repair of damaged muscle fibers by promoting myoblast fusion and new muscle fiber formation. MGF also inhibits apoptosis in muscle cells by enhancing Akt phosphorylation, improving cell survival and recovery after injury or strenuous physical activity.

Neuroprotection:

In the central nervous system (CNS), MGF activates neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), which support neuronal survival, synaptic plasticity, and cognitive function. Additionally, MGF reduces neuronal apoptosis by stimulating the PI3K/Akt pathway, protecting neurons from ischemic injury, oxidative stress, and neurodegenerative processes. This suggests potential therapeutic applications for stroke recovery, neurodegenerative diseases, and brain trauma rehabilitation.