Pancragen

Pancragen is a short synthetic peptide targeting pancreatic tissue to restore β-cell activity, reduce oxidative stress, and improve insulin/glucagon balance. It promotes protein synthesis and pancreatic repair through gene modulation.

- Manage blood sugar irregularities

- Support pancreatic repair and metabolism

Mechanism of Action

How this peptide works in the body

Chromatin Remodeling and Pancreatic Gene Reactivation

Pancragen promotes chromatin decondensation in pancreatic endocrine cells, allowing increased transcription of key regulatory genes including insulin (INS), glucokinase (GCK), and PDX1. This is achieved through enhanced histone acetylation (H3K9ac, H3K27ac) and reduced repressive methylation marks (H3K27me3), facilitating β-cell regeneration and function.

Epigenetic Modulation and Insulin Axis Sensitivity

The peptide modulates the epigenetic landscape of pancreatic islets by activating histone acetyltransferases (HATs) and suppressing histone deacetylases (HDACs), increasing accessibility to genes regulating glucose sensing and insulin secretion. It may also upregulate TET enzymes, reversing aberrant promoter methylation at key loci including MAFA and PDX1.

Anti-Inflammatory Effects in Islet Microenvironment

Pancragen reduces pro-inflammatory cytokine expression (IL-1β, TNF-α, IFN-γ) by inhibiting NF-κB signaling in pancreatic stromal and immune-infiltrating cells. It downregulates inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), mitigating β-cell apoptosis and preserving islet architecture.

Oxidative Stress Reduction and β-Cell Longevity

The peptide activates Nrf2 transcription factor in β-cells, enhancing antioxidant responses including upregulation of catalase, superoxide dismutase, and peroxiredoxins. This protects against ROS-induced DNA damage, a major contributor to islet cell senescence in diabetes.

Pancreatic Enzyme Regulation and Digestive Function

In exocrine tissues, Pancragen increases the transcription of digestive enzymes like amylase and lipase while protecting acinar cells from inflammatory stress. This supports improved digestion and nutrient assimilation, especially in individuals with subclinical pancreatic insufficiency.