Pielotax is a renal-specific peptide complex that restores kidney function by targeting renal tubular and mesangial cells. It modulates gene expression to repair tissue, reduce inflammation, and improve glomerular filtration.
Pielotax
Also known as: A-9 Kidney Peptide Bioregulator
Overview
Benefits
- Improves nephron filtration
- Reduces renal inflammation
- Reverses fibrosis
- Supports erythropoietin output
- Aids recovery from nephrotoxicity
Consider This Peptide If You Want To
- Support kidney repair and reduce inflammation
- Aid renal recovery post-medication or illness
Dosage & Administration
Dosage Guidelines
Recommended Dosage
• Amount:30 mg
• Frequency:daily
• Duration:4 weeks
• Rest Period:12 weeks
• Time of Day:morning
• Ingestion:oral
Take with food to optimize absorption. Monitor kidney function during treatment.
Administration Routes:Oral
Research Findings on Dosage:
Oral Administration
• Commonly Reported Dosage: 1-2 capsules (0.215 g each) twice daily (this equates to 20-40 mg of peptide complex A-9)
• Duration: 30 days, repeat every 4--6 months chronically, or more frequently in acute support phases
Administration Notes: Take with food to optimize absorption and renal metabolism
Mechanism of Action
Mechanism of Action
How this peptide works in the body
Chromatin Remodeling in Renal Tissue
Pielotax increases euchromatin availability in renal tubular epithelial cells by upregulating histone acetylation marks (e.g., H3K9ac, H3K27ac), while decreasing repressive marks like H3K27me3. This promotes transcription of genes such as SLC12A3 (a sodium-chloride transporter), AQP2 (aquaporin-2), and EPO (erythropoietin).
Renal Anti-Inflammatory Signaling
It suppresses activation of NF-κB in mesangial and tubular cells, decreasing expression of MCP-1, IL-6, and TNF-α. Pielotax also reduces leukocyte adhesion molecule expression (ICAM-1, VCAM-1), protecting glomeruli from immune infiltration and fibrosis.
Fibrosis Regulation and ECM Remodeling
Pielotax inhibits TGF-β1-induced fibrotic signaling by downregulating SMAD2/3 phosphorylation. It upregulates MMP-2 and MMP-9 and decreases TIMP expression, supporting extracellular matrix (ECM) clearance and reducing renal interstitial fibrosis.
Electrolyte Transport and Nephron Function
Through upregulation of SLC transporter genes and Na+/K+ ATPase expression, Pielotax enhances reabsorption efficiency in distal and collecting tubules. It improves urine concentrating ability and restores solute balance in chronic kidney impairment.
Hormonal Modulation and Erythropoiesis
Pielotax promotes expression of erythropoietin in peritubular fibroblasts by relieving epigenetic repression of the EPO gene. It may indirectly normalize renin-angiotensin signaling by restoring baroreceptor feedback sensitivity in juxtaglomerular cells.
Consider Stacking With
- Ventfort
- Thymalin
- Endoluten
- Livagen
- Glandokort
Side Effects & Cautions
Common Side Effects
- None documented
Cautions
- Use under supervision for renal disease
- Monitor when on diuretics/antihypertensives
Rare Side Effects
- Rare allergic reactions
Research & References
Research Highlights
Khavinson et al., 2022: Reported nephroprotective gene upregulation and inflammation reduction in renal cell cultures treated with Pielotax.
Trofimova et al., 2013: Demonstrated improved creatinine clearance and reduced proteinuria in early-stage CKD patients after peptide use.
Umnov et al., 2011: Observed ECM remodeling and reduced mesangial matrix expansion in biopsy-confirmed nephropathy cases.
Khavinson & Morozov, 2009: Identified epigenetic gene activation pathways specific to renal peptide bioregulators.
References
Khavinson V, et al. "Peptide regulation of renal gene networks in nephropathy models." Int J Mol Sci. 2022.
Trofimova SV, et al. "Efficacy of peptide complexes in early chronic kidney disease." Russian J Gerontology. 2013.
Umnov RS, et al. "Histological evaluation of renal bioregeneration using short peptides." Peptide Therapy Reports. 2011.
Khavinson V, Morozov VG. "Tissue-specific peptides in renal repair and aging." 2009.