Prostamax

Prostamax is a prostate-specific peptide complex that restores prostate structure and function, regulates androgens, reduces inflammation, and supports hormonal balance in age-related decline and BPH.

- Support prostate health and hormonal balance

- Relieve urinary symptoms or inflammation

Mechanism of Action

How this peptide works in the body

Epigenetic Regulation in Prostatic Epithelial Cells

Prostamax enhances acetylation of histones H3 and H4 in epithelial nuclei, facilitating transcription of genes involved in tissue architecture (e.g., KLK3, AR, NKX3.1). These changes restore secretory function and glandular homeostasis. The increased chromatin accessibility improves luminal cell differentiation and androgen responsiveness.

Androgen Receptor Pathway Modulation

The peptide upregulates androgen receptor coactivators (e.g., NCOA1, p300) and downregulates inflammatory repressors that interfere with DHT signaling. This leads to improved transcriptional control over prostate-specific genes and a better-regulated testosterone-DHT conversion axis, reducing hyperplastic signaling.

Anti-Inflammatory Activity in Prostatic Stroma

Prostamax reduces NF-κB nuclear translocation in stromal fibroblasts, leading to decreased expression of IL-6, TNF-α, and COX-2. This dampens paracrine inflammatory cascades, particularly in chronic prostatitis. It also inhibits mast cell degranulation, which can trigger nociceptive symptoms and fibrotic remodeling.

Inhibition of Fibrosis and ECM Remodeling

The peptide inhibits TGF-β1/SMAD3-driven collagen deposition while increasing expression of MMP-1 and MMP-9. This counteracts fibrotic thickening of the prostate capsule and periurethral zones, improving urinary flow. Prostamax additionally boosts decorin expression, which acts as a natural TGF-β antagonist.

Support of Prostate Stem/Progenitor Cell Renewal

Prostamax stimulates Sox9 and Wnt/β-catenin signaling in basal cells, promoting replenishment of the epithelial layer. This contributes to long-term tissue integrity and functional rejuvenation, especially in aging prostate tissue.