Sermorelin is a GHRH analog comprising the first 29 amino acids of native GHRH. It binds pituitary GHRH receptors to stimulate endogenous GH secretion in a natural pulsatile rhythm. It supports growth, metabolism, and tissue repair while maintaining hormonal feedback control.
Sermorelin
Also known as: GRF 1-29; Geref; Sermorelin Acetate
Overview
Benefits
- Growth hormone support
- Muscle growth
- Fat loss
- Anti-aging
- Tissue repair
- Heart health
Consider This Peptide If You Want To
- Stimulate GH naturally for muscle, recovery, and fat loss
- Improve sleep, repair, and vitality
Dosage & Administration
Dosage Guidelines
Recommended Dosage
• Amount:100 mcg
• Frequency:weekdays
• Duration:10 weeks
• Rest Period:8 weeks
• Time of Day:evening
• Ingestion:subcutaneous
Administration Routes:Subcutaneous
Research Findings on Dosage:
Subcutaneous Injection:
• Commonly Reported Dosage: 100-300 mcg subcutaneously (SQ), 5 days on, 2 days off, typically at bedtime.
• Duration: 10-12 weeks on, 4-8 weeks off
• Notes: Near bedtime or around workouts for growth hormone release. Optimal effects achieved in a fasted state.
Mechanism of Action
Mechanism of Action
How this peptide works in the body
GHRH Receptor Activation:
Sermorelin binds to GHRH receptors in the anterior pituitary gland, stimulating the somatotropic cells to release growth hormone (GH). This binding activates the G-protein-coupled receptor (GPCR) pathway, leading to cyclic AMP (cAMP) production and subsequent calcium influx, which triggers GH secretion.
Somatostatin Feedback Regulation:
Unlike exogenous GH, sermorelin does not bypass somatostatin-mediated feedback, ensuring balanced endogenous GH levels. By preserving the natural inhibitory effect of somatostatin, sermorelin prevents excessive GH release and supports homeostatic endocrine control.
Tissue Repair and Metabolism:
Enhances IGF-1 production in the liver, promoting tissue repair, cellular growth, and metabolic balance. IGF-1, acting through the IGF-1 receptor, stimulates anabolic processes such as protein synthesis and inhibits proteolysis, critical for muscle and tissue regeneration.
Neuroprotection:
Stimulates neurotrophic factors, potentially supporting cognitive functions and brain health. This involves upregulation of brain-derived neurotrophic factor (BDNF) and other growth factors, which facilitate synaptic plasticity and neuronal survival under stress or injury conditions.
Consider Stacking With
- Any GHRP (Ipamorelin, Hexarelin)
- BPC-157
- TB-4
- AOD-9604
- Semaglutide/Tirzepatide
- PEG-MGF
- Kisspeptin-10
- 5-Amino-1MQ
Side Effects & Cautions
Common Side Effects
- Injection site redness or pain
- Water retention
Cautions
- Banned by WADA; avoid in athletes
- Monitor if autoimmune response suspected
Rare Side Effects
- Possible anti-GHRH antibody formation
Research & References
Research Highlights
Growth Hormone Deficiency:
Effective in stimulating GH release for both diagnostic and therapeutic purposes.
Provides a safer alternative to recombinant human growth hormone (rhGH).
Anti-Aging:
Studies show improvements in lean body mass, skin thickness, and overall well-being in elderly subjects.
Neuroprotection:
Potential benefits in reducing seizure activity and supporting cognitive health.
Cardiac Health:
Demonstrated benefits in post-heart attack animal models, reducing scarring and enhancing vascular growth.
Wound Healing:
Enhances collagen synthesis, promoting faster recovery of skin and connective tissues.
References
PubMed: Sermorelin and Growth Hormone Deficiency
Neuroprotective Effects of GHRH Analogues
Sermorelin as an Anti-Aging Therapy
Cardiac Benefits of GHRH Analogues