Suprefort

Suprefort is a pancreatic-specific peptide that regulates gene expression in beta cells to support insulin production, reduce inflammation, and improve glucose metabolism. Used for metabolic syndrome and type 2 diabetes support.

- Improve blood sugar control and metabolic function

- Support pancreatic repair

Mechanism of Action

How this peptide works in the body

Stimulation of Beta Cell Gene Networks

Suprefort increases acetylation and H3K4 trimethylation at the promoters of PDX1, MAFA, and INS1 genes, which are critical for beta cell identity and insulin biosynthesis. These chromatin modifications enhance the transcriptional machinery needed for glucose-sensing and insulin production. It also suppresses repressive methylation at the ARX locus, which antagonizes alpha-to-beta cell transdifferentiation.

Modulation of Inflammatory Pathways in Pancreatic Tissue

The peptide inhibits NF-κB and JNK signaling pathways in pancreatic acinar and immune-infiltrating cells. This leads to decreased expression of IL-1β, TNF-α, and IL-6---cytokines known to drive beta cell apoptosis and insulin resistance. Suprefort also promotes the secretion of IL-10 and TGF-β, fostering a regulatory immune phenotype that protects islet architecture.

Enhancement of Insulin Signaling and Glucose Uptake

Suprefort upregulates the expression of IRS-1 and GLUT4 in skeletal muscle and adipose tissue via pancreas-mediated hormonal modulation. This amplifies insulin signal transduction through the PI3K/Akt pathway, improving glucose uptake and glycogen storage. It indirectly increases adiponectin levels, enhancing insulin sensitivity.

Support of Islet Regeneration and Neogenesis

The peptide promotes pancreatic progenitor cell proliferation by upregulating SOX9, NGN3, and HNF6 expression in ductal niches. This encourages differentiation into insulin-producing cells and may reverse partial beta cell loss. It also activates Notch signaling in a controlled fashion, maintaining progenitor pools while preventing premature depletion.

Normalization of Digestive Enzyme Secretion

Suprefort restores gene expression of trypsinogen, amylase, and lipase in pancreatic acinar cells, improving macronutrient digestion and postprandial glycemic regulation. It reduces ER stress and supports zymogen granule biogenesis via upregulation of XBP1 and ATF6.