Taxorest

Taxorest is a bronchial mucosa-derived peptide that regenerates epithelial tissue, restores cytokine balance, and enhances antioxidant defenses for respiratory recovery. Used in chronic lung and toxin exposure contexts.

- Recover from respiratory illness or chronic inflammation

- Improve lung capacity

Mechanism of Action

How this peptide works in the body

Epithelial Regeneration via Chromatin Remodeling

Taxorest induces acetylation of histones H3 and H4 at gene promoters such as MUC5B and FOXJ1, which are critical for mucociliary clearance and epithelial differentiation. These modifications promote euchromatin formation and upregulate the expression of secretory and ciliated cell lineages. The net effect is a restoration of bronchial epithelial integrity and function, especially in tissues damaged by inflammation or toxins.

Modulation of Pulmonary Immune Response

The peptide downregulates NF-κB and AP-1 transcription factors by interfering with upstream MAPK and IKK signaling in bronchial epithelial and resident macrophage populations. This suppresses pro-inflammatory cytokines (e.g., TNF-α, IL-1β) while promoting regulatory signals like IL-10. Taxorest also reduces neutrophil infiltration by lowering CXCL8 expression, preventing excess tissue destruction.

Antioxidant Activation through Nrf2 Pathway

Taxorest upregulates Nrf2 translocation into the nucleus by inhibiting KEAP1 ubiquitination processes. Once activated, Nrf2 binds to ARE sequences in genes encoding antioxidant enzymes such as SOD1, GPX1, and HO-1. This increases the antioxidant capacity of bronchial epithelial cells, reducing ROS-induced cellular damage and supporting long-term lung tissue viability.

Support of Pulmonary Matrix Remodeling

By decreasing the expression of TGF-β1 and TIMP-1, Taxorest reduces fibrotic signaling while promoting MMP9 activity, enabling resolution of extracellular matrix (ECM) overgrowth. This helps normalize bronchial architecture, particularly in post-infectious fibrosis or age-related ECM stiffness. It also facilitates the clearance of damaged matrix and recruitment of regenerative fibroblasts.

Enhancement of Oxygen Exchange Capacity

Taxorest modulates the expression of aquaporins (AQP5) and surfactant protein genes (SFTPB, SFTPD), both crucial for alveolar hydration and surface tension regulation. This improves gas exchange efficiency and supports alveolar elasticity, particularly under chronic stress or low-grade hypoxia. It may also enhance vascular perfusion in alveolar capillaries via upregulation of eNOS and VEGF expression.