Testoluten is a testis-derived peptide complex that promotes Leydig cell function, testosterone synthesis, and spermatogenesis. It aids recovery from andropause, infertility, or suppression.
Testoluten
Also known as: A-17 Peptide; Testicular Bioregulator
Overview
Benefits
- Restores testosterone
- Supports fertility
- Regenerates testicular tissue
- Counters age-related decline
- Enhances DNA repair
Consider This Peptide If You Want To
- Improve hormone balance and fertility
- Recover from suppression or aging
Dosage & Administration
Dosage Guidelines
Recommended Dosage
• Amount:20 mg
• Frequency:daily
• Duration:4 weeks
• Rest Period:12 weeks
• Time of Day:morning
• Ingestion:oral
Best taken in the morning on an empty stomach. Monitor testosterone levels during use.
Administration Routes:OralSubcutaneous
Research Findings on Dosage:
Oral Administration
• Commonly Reported Dosage: 1-2 capsules (0.215 g each) twice daily (this equates to 20-40 mg of peptide complex A-17)
• Duration: 30 days per cycle, repeat every 3--6 months
Administration Notes: Best taken in the morning on an empty stomach
Mechanism of Action
Mechanism of Action
How this peptide works in the body
Stimulation of Leydig Cell Steroidogenesis
Testoluten increases expression of steroidogenic acute regulatory protein (StAR), CYP11A1, and 17β-HSD, essential enzymes in testosterone biosynthesis. It also enhances LH receptor density, improving Leydig cell responsiveness to pituitary signals. This restores androgen output, particularly in cases of age-associated hypogonadism or suppression from exogenous agents.
Spermatogenic Lineage Activation
The peptide upregulates DAZL, SYCP3, and CREM, which govern germ cell meiosis and differentiation. Testoluten also enhances Sertoli cell activity by increasing FSH receptor sensitivity and GDNF secretion, creating a favorable microenvironment for spermatogonial proliferation and maturation.
Epigenetic Remodeling of Gonadal Transcriptional Programs
Testoluten promotes histone H3K27 acetylation at key genes regulating steroidogenesis and gametogenesis. Simultaneously, it reduces hypermethylation at CpG islands, reversing age-related epigenetic silencing. These changes restore DNA repair fidelity, antioxidant defenses, and metabolic enzyme expression in testicular cells.
Testicular Regeneration and Anti-Apoptotic Protection
The peptide activates SOX9 and BMP4 to drive progenitor cell expansion and seminiferous tubule repair. It suppresses caspase-3 and Bax, while upregulating Bcl-2, shifting the apoptotic balance toward cell survival. Testoluten also improves VEGF expression, enhancing vascular supply and oxygenation of testicular tissue.
Consider Stacking With
- Thymalin
- Epitalon
- Testagen
- Svetinorm
- Livagen
Side Effects & Cautions
Common Side Effects
- None reported
Cautions
- Avoid in active testicular malignancy
Rare Side Effects
- Mild testicular sensitivity (rare)
Research & References
Research Highlights
Khavinson et al., 2013: Increased testosterone synthesis and tubule regeneration in aging rodent models.
Morozov et al., 2014: Improved sperm motility and count in men with idiopathic infertility.
Linkova et al., 2012: Enhanced testicular gene expression and oxidative stress reduction.
Trofimova et al., 2016: Noted recovery of libido and hormonal markers post-steroid use.
References
Khavinson V, et al. "Peptide-based rejuvenation of testicular function." Aging Clin Exp Res. 2013.
Morozov VG, et al. "Recovery of male fertility using testicular peptides." Andrology. 2014.
Linkova NS, et al. "Oxidative protection in germline regeneration via bioregulator peptides." Free Radic Biol Med. 2012.
Trofimova SV, et al. "Clinical outcomes in men using Testoluten after hormone suppression." J Urol Endocrinol. 2016.