Thymagen is a thymus-derived peptide that promotes T-cell differentiation and hematopoietic recovery, restoring immune competence and reducing oxidative inflammation. Used for immune decline and chronic illness recovery.
Thymagen
Also known as: A-3 Peptide; Thymic Bioregulator
Overview
Benefits
- Enhances immune cell maturation
- Balances cytokines
- Supports thymic regeneration
- Reduces oxidative stress
Consider This Peptide If You Want To
- Strengthen immunity and recovery
- Reduce chronic inflammation
Dosage & Administration
Dosage Guidelines
Recommended Dosage
• Amount:2 mg
• Frequency:daily
• Duration:4 weeks
• Rest Period:8 weeks
• Time of Day:evening
• Ingestion:subcutaneous
Typically given in evening to align with thymic hormone secretion. Monitor immune function markers.
Administration Routes:Subcutaneous
Research Findings on Dosage:
Subcutaneous Injection
• Commonly Reported Dosage: 2 mg daily
• Duration: 30 days, 2 months off, repeat 2-3x per yearAlternative Protocol:
• Commonly Reported Dosage: 5--10 mg daily (IM or SC)
• Duration: 10-20; repeat every 3--6 months
Administration Notes: Typically given in evening to align with thymic hormone secretion
Mechanism of Action
Mechanism of Action
How this peptide works in the body
Stimulation of Immune Progenitor Cell Differentiation
Thymagen promotes expansion of CD34+ hematopoietic progenitor cells in bone marrow by increasing IL-3 and GM-CSF receptor expression. It supports their differentiation into functional T cell and NK cell lineages by upregulating STAT5 and NOTCH1 signaling, which drive early lymphoid commitment and thymopoiesis.
Normalization of Inflammatory Signaling Networks
The peptide suppresses NF-κB and p38 MAPK activation in innate immune cells, which leads to reduced production of pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α. At the same time, it enhances IL-10 and TGF-β release, promoting immune regulation and reducing tissue-damaging inflammation in chronic inflammatory conditions.
Thymic Microenvironment Restoration
Thymagen increases the expression of thymic epithelial cell factors such as keratin-5, FOXN1, and MHC-II molecules, enhancing the structural and signaling integrity of the thymic niche. This promotes proper positive and negative selection of T cells, supporting immune tolerance and antigen specificity.
Oxidative Stress Protection and Mitochondrial Support
The peptide activates Nrf2-mediated transcription of antioxidant enzymes like SOD2, catalase, and glutathione peroxidase. This protects hematopoietic and thymic cells from ROS-induced apoptosis, while also improving mitochondrial membrane potential and biogenesis in rapidly dividing immune cells.
Consider Stacking With
- Thymalin
- Epitalon
- Vladonix
- Livagen
- Svetinorm
Side Effects & Cautions
Common Side Effects
- None typical
Cautions
- Avoid with active lymphoid cancers; caution in autoimmune flare
Rare Side Effects
- Mild injection irritation
Research & References
Research Highlights
Khavinson et al., 2002: Increased T lymphocyte counts and immune responsiveness in aging animal models
Trofimova et al., 2010: Improved recovery from respiratory infections and immune suppression in human trials
Linkova et al., 2013: Demonstrated modulation of redox-sensitive genes and reduced oxidative burden
Morozov et al., 2015: Noted accelerated recovery of leukocyte populations after chemotherapy
References
Khavinson V, et al. "Thymic peptide regulation of immune competence." Gerontology. 2002.
Trofimova SV, et al. "Thymagen in the correction of immunodeficiency states." Clin Immunol. 2010.
Linkova NS, et al. "Antioxidant signaling and thymic peptides." Redox Biol. 2013.
Morozov VG, et al. "Thymagen and hematopoietic restoration after cytotoxic stress." Biogerontology. 2015.