Thyreogen

Thyreogen is a thyroid-derived peptide that restores T3/T4 production, modulates the HPT axis, and protects against thyroid inflammation. It enhances metabolic and mitochondrial function in thyroid aging or dysfunction.

- Manage low thyroid or metabolic slowdown

- Recover from thyroid inflammation or stress

Mechanism of Action

How this peptide works in the body

Regulation of Thyroid Hormone Biosynthesis

Thyreogen upregulates genes involved in thyroid hormone production including TPO (thyroid peroxidase), TG (thyroglobulin), and NIS (sodium-iodide symporter). It also enhances transcription of TSH receptor genes, increasing follicular cell sensitivity to pituitary signaling. These changes boost T3/T4 output while maintaining physiological feedback loops within the HPT axis.

Epigenetic Reprogramming of Thyroid Gene Expression

The peptide promotes H3K9 and H3K27 acetylation at promoter regions of thyroid-specific genes, increasing chromatin accessibility and restoring youthful gene transcription patterns. It also suppresses age-related hypermethylation at CpG islands that control metabolic and antioxidant response genes, preserving thyroid cellular function under stress.

Modulation of Inflammatory and Autoimmune Signals

Thyreogen inhibits NF-κB and STAT1 signaling pathways in thyroid epithelial and immune cells, reducing expression of CXCL10, IFN-γ, and other markers implicated in autoimmune thyroiditis. It fosters a tolerogenic environment by promoting IL-10 and TGF-β secretion, helping protect thyroid tissue from chronic inflammatory assault.

Improvement of Mitochondrial Efficiency and Redox Balance

The peptide stimulates PGC-1α and SIRT3 in thyroid cells, enhancing mitochondrial biogenesis and respiration. It activates NRF2-mediated antioxidant pathways and reduces NOX4 expression, protecting against ROS-induced thyrocyte damage. These mechanisms improve ATP production and hormone biosynthesis efficiency under metabolic stress.