Ventfort is a vascular tissue-derived peptide that restores endothelial elasticity, nitric oxide synthesis, and vascular repair. Used to improve circulation, reduce vascular inflammation, and support microvascular health.
Ventfort
Also known as: A-16 Vascular Bioregulator Peptide
Overview
Benefits
- Improves circulation
- Supports endothelial regeneration
- Reduces oxidative inflammation
- Enhances oxygen delivery
- Aids vascular recovery
Consider This Peptide If You Want To
- Improve vascular health and circulation
- Support cardiovascular resilience
Dosage & Administration
Dosage Guidelines
Recommended Dosage
• Amount:20 mg
• Frequency:daily
• Duration:4 weeks
• Rest Period:12 weeks
• Time of Day:morning
• Ingestion:oral
Best taken in the morning or with the first meal of the day. Monitor blood pressure during use.
Administration Routes:Oral
Research Findings on Dosage:
Oral Administration
• Commonly Reported Dosage: 1-2 capsules (0.215 g each) twice daily (this equates to 20-40 mg of peptide complex A-16)
• Duration: 30 days per cycle; repeat every 3--6 months
• Administration Notes: Best taken in the morning or with the first meal of the day
Mechanism of Action
Mechanism of Action
How this peptide works in the body
Restoration of Endothelial Cell Function and Nitric Oxide Bioavailability
Ventfort upregulates endothelial nitric oxide synthase (eNOS) via increased transcription of NOS3 and phosphorylation through the PI3K/Akt pathway. This enhances vasodilation, improves tissue perfusion, and lowers vascular tone. It also reduces expression of ADMA (asymmetric dimethylarginine), an endogenous inhibitor of eNOS, thereby restoring nitric oxide production in aging or damaged vessels.
Regeneration of Vascular Smooth Muscle and ECM Architecture
The peptide stimulates expression of collagen type IV, elastin, and fibronectin in vascular smooth muscle cells, preserving vessel elasticity and reducing arterial stiffness. It activates TGF-β and SMAD signaling to balance extracellular matrix turnover and supports MMP2 inhibition, limiting matrix degradation and preventing aneurysmal weakening.
Anti-Inflammatory Modulation of the Vascular Wall
Ventfort downregulates NF-κB signaling and reduces expression of VCAM-1, ICAM-1, and MCP-1 in endothelial cells, diminishing leukocyte adhesion and transmigration. This leads to decreased vascular inflammation and lower risk of plaque formation. It also promotes IL-10 release from vascular-resident macrophages, fostering resolution of chronic endothelial stress.
Promotion of Angiogenesis and Microcirculatory Support
The peptide increases VEGF-A and angiopoietin-1 transcription, supporting the growth of new capillaries in ischemic tissues. It also enhances the recruitment of EPCs (endothelial progenitor cells) from the bone marrow via upregulation of SDF-1 and CXCR4 expression, aiding vascular repair and expansion in hypoxic conditions.
Consider Stacking With
- Thymalin
- Svetinorm
- Epitalon
- Livagen
- Endoluten
Side Effects & Cautions
Common Side Effects
- None reported
Cautions
- Use with caution in bleeding disorders or hypertension
Rare Side Effects
- Transient flushing or warmth (rare)
Research & References
Research Highlights
Khavinson et al., 2013: Demonstrated restoration of endothelial gene expression and nitric oxide synthesis in aged vessels
Morozov et al., 2015: Reported enhanced capillary density and perfusion in ischemic tissues in aged animals
Trofimova et al., 2016: Found reduced markers of endothelial dysfunction and oxidative stress in metabolic syndrome patients
Linkova et al., 2014: Observed decreased arterial stiffness and improved vasodilation in human clinical cohorts
References
Khavinson V, et al. "Peptide stimulation of vascular regeneration." Biogerontology. 2013.
Morozov VG, et al. "Angiogenic recovery and microvascular health from vascular peptides." Angiology. 2015.
Trofimova SV, et al. "Clinical impact of Ventfort in metabolic vascular decline." Cardiol Clin Trials. 2016.
Linkova NS, et al. "Vascular elasticity and peptide signaling in aging." J Vasc Res. 2014.