Vesilut

Vesilut is a bladder-specific peptide that supports urothelial repair, detrusor function, and inflammatory modulation. Used for cystitis, bladder pain, and urogenital dysfunction.

- Manage chronic cystitis or urological inflammation

- Improve urinary comfort and control

Mechanism of Action

How this peptide works in the body

Regulation of Urothelial Regeneration and Barrier Integrity

Vesilut promotes transcription of E-cadherin, claudins, and uroplakin genes---essential for maintaining tight junctions and a protective urothelial barrier. It enhances basal cell proliferation via upregulation of SOX9 and CK5, contributing to epithelial renewal. These effects protect against urinary irritants and reduce permeability-linked inflammation.

Reduction of Inflammatory Mediators in Bladder Tissue

The peptide inhibits the COX-2 and NF-κB pathways in bladder epithelial and immune cells, reducing prostaglandin E2 and cytokines like IL-1β and TNF-α. It promotes the release of anti-inflammatory mediators (IL-10, TGF-β) and limits mast cell degranulation, which are often elevated in interstitial cystitis and chronic bladder pain syndromes.

Neuromodulation of Bladder Contractility and Sensory Signaling

Vesilut increases expression of muscarinic M2/M3 and β3-adrenergic receptors in detrusor muscle, restoring balance between contraction and relaxation. It also downregulates TRPV1 and P2X3 receptors in bladder afferents, reducing pain transmission and urgency signals. This dual modulation improves voiding control and reduces hypersensitivity.

Epigenetic Activation of Bladder-Specific Repair Genes

Through histone acetylation (H3K27ac) and demethylation of repair gene promoters, Vesilut enhances transcription of regenerative transcription factors like GATA3, P63, and HOXA13. These support urothelial stem cell differentiation and stratification, critical for maintaining tissue integrity in aging or inflamed bladders.