Vladonix

Vladonix is a thymic peptide that restores immune balance, supports T-cell maturation, and reduces systemic inflammation in aging or immunodeficiency.

- Strengthen immunity after illness or aging

- Restore immune balance

Mechanism of Action

How this peptide works in the body

Restoration of Thymic Epithelial Function and T-Cell Differentiation

Vladonix promotes transcription of FOXN1 and AIRE genes in thymic epithelial cells (TECs), both of which are essential for the development of functional, self-tolerant T cells. Through epigenetic remodeling (e.g., H3K27ac), it enhances the expression of IL-7 and CCL25, supporting thymocyte proliferation and guidance. This contributes to improved CD4/CD8 cell balance and immune responsiveness.

Rebalancing of Immune Cytokine Profiles

The peptide downregulates NF-κB signaling in dendritic and T-helper cells, reducing excessive secretion of TNF-α, IL-1β, and IL-6. Simultaneously, it increases IL-10 and TGF-β1, shifting the immune response toward a regulatory and anti-inflammatory phenotype. This rebalancing is particularly beneficial in autoimmune and chronic inflammatory settings.

Support of Peripheral Immune Surveillance and Cell-Mediated Immunity

Vladonix enhances expression of perforin and granzyme B in CD8+ T cells and NK cells, strengthening cytotoxic immune responses. It also increases MHC class I and II expression in antigen-presenting cells, improving adaptive immune engagement. These changes boost pathogen clearance while preserving tissue-specific immune tolerance.

Preservation of Hematopoietic Stem Cell Function Under Immune Stress

The peptide supports hematopoietic niche homeostasis via SCF/c-Kit and CXCL12-CXCR4 signaling pathways. This maintains a functional stem cell reserve capable of producing balanced immune cell lineages. It also reduces apoptosis of progenitor cells by modulating Bcl-2 and caspase expression, especially under inflammatory or oxidative challenge.