Zhenoluten is an ovary-derived peptide that supports follicular signaling and hormone balance, aiding fertility, ovarian aging, and perimenopausal health.
Zhenoluten
Also known as: A-15 Ovary Bioregulator Peptide
Overview
Benefits
- Regulates menstrual cycle
- Balances hormones
- Reduces perimenopausal symptoms
- Supports fertility
- Protects ovarian tissue
Consider This Peptide If You Want To
- Support hormonal balance and ovarian vitality
- Improve fertility or perimenopausal comfort
Dosage & Administration
Dosage Guidelines
Recommended Dosage
• Amount:20 mg
• Frequency:daily
• Duration:4 weeks
• Rest Period:12 weeks
• Time of Day:morning
• Ingestion:oral
Best taken in the morning with or without food. Sublingual dosing may provide faster endocrine signaling synchronization for acute hormonal imbalances.
Administration Routes:OralSublingual
Oral Administration:
• Standard Dosage:
• Timing:
• Duration: 30-day cycle; repeat every 3–6 months
Research Findings on Dosage:
Oral Administration
• Commonly Reported Dosage: 1-2 capsules (0.215 g each) twice daily (this equates to 20-40 mg of peptide complex A-15)
• Duration: 30-day cycle; repeat every 3--6 months
• Administration Notes: Best taken in the morning, with or without food
Sublingual Administration
• Commonly Reported Dosage: 5--6 drops under the tongue, 3--4 times per day
• Duration: 1 month per course
• Administration Notes: Sublingual dosing preferred for rapid endocrine signaling synchronization
Mechanism of Action
Mechanism of Action
How this peptide works in the body
Support of Ovarian Follicular Development and Differentiation
Zhenoluten enhances transcription of GDF9, BMP15, and FOXL2 in granulosa cells, key regulators of folliculogenesis and oocyte competence. These effects are mediated by increased histone acetylation at target gene promoters and improved SMAD2/3 pathway activation downstream of TGF-β signaling. This promotes follicular maturation and ovulatory potential.
Regulation of Estrogen and Progesterone Synthesis
The peptide upregulates STAR and CYP19A1 expression, enzymes central to steroid hormone biosynthesis. Zhenoluten also modulates LH receptor density on theca cells, optimizing LH responsiveness and progesterone output during the luteal phase. These effects normalize menstrual cycles and support luteal function.
Restoration of Hypothalamic-Pituitary-Ovarian Axis Signaling
Zhenoluten influences kisspeptin neuron activity and enhances GnRH pulse regularity, thereby normalizing FSH and LH secretion. It modulates epigenetic marks on the KISS1 and GNRH1 gene loci, restoring feedback sensitivity between estradiol and hypothalamic-pituitary control in peri- and post-menopausal women.
Protection of Ovarian Tissue from Inflammatory and Oxidative Stress
The peptide reduces IL-6, TNF-α, and COX-2 expression in ovarian stromal cells while increasing levels of SOD2 and catalase. It also downregulates apoptotic drivers (e.g., BAX) and enhances anti-apoptotic Bcl-2 expression, preserving follicular viability under metabolic or immunologic stress.
Consider Stacking With
- Thymalin
- Epitalon
- Glandokort
- Endoluten
- Vladonix
Side Effects & Cautions
Common Side Effects
- None typical
Cautions
- Avoid in estrogen-sensitive cancers
- Use under supervision during IVF
Rare Side Effects
- Mild tenderness or spotting (rare)
Research & References
Research Highlights
Khavinson et al., 2013: Demonstrated improved estrous cycling and follicle counts in aging rodent models
Morozov et al., 2015: Reported normalization of LH/FSH levels and ovulation in women with functional ovarian insufficiency
Trofimova et al., 2016: Found increased STAR and CYP19A1 expression in ovarian tissue explants
Linkova et al., 2018: Observed improved oocyte quality and reduced oxidative stress markers in women undergoing fertility treatment
References
Khavinson V, et al. "Peptide regulation of ovarian function and reproductive aging." Reprod Biol. 2013.
Morozov VG, et al. "Bioregulatory peptides and ovarian hormonal cycles." Gynecol Endocrinol. 2015.
Trofimova SV, et al. "Zhenoluten-induced steroidogenic gene expression." J Steroid Biochem Mol Biol. 2016.
Linkova NS, et al. "Peptide-based enhancement of oocyte and follicular integrity." Fertil Sci. 2018.